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Cardiology
33 trials
Framingham Heart Study
Started in 1948 with 5,209 residents of Framingham, Massachusetts, this cohort study transformed cardiology. Before Framingham, he...
4S
The Scandinavian Simvastatin Survival Study randomized 4,444 patients with prior heart attack or angina and high cholesterol to si...
WOSCOPS
The West of Scotland Coronary Prevention Study randomized 6,595 healthy men with elevated LDL cholesterol to pravastatin or placeb...
Heart Protection Study
HPS randomized 20,536 UK adults with vascular disease or diabetes to simvastatin 40 mg or placebo regardless of baseline cholester...
JUPITER
Justification for the Use of Statins in Prevention trial tested rosuvastatin in 17,802 healthy people with low LDL under 130 but e...
FOURIER
FOURIER randomized 27,564 patients with atherosclerotic disease on optimized statins to the PCSK9 inhibitor evolocumab or placebo....
ISIS-2
The Second International Study of Infarct Survival randomized 17,187 heart attack patients to streptokinase, aspirin, both, or nei...
GUSTO-I
GUSTO-I randomized 41,021 heart attack patients to four thrombolytic strategies. Accelerated tissue plasminogen activator with hep...
CAST
The Cardiac Arrhythmia Suppression Trial tested whether suppressing ventricular premature beats after heart attack prevented death...
HOPE
The Heart Outcomes Prevention Evaluation trial randomized 9,297 patients with vascular disease or diabetes plus one risk factor to...
ALLHAT
The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial randomized over 42,000 hypertensive patients to ch...
SPRINT
The Systolic Blood Pressure Intervention Trial randomized 9,361 adults over 50 with hypertension and cardiovascular risk to systol...
SHEP
The Systolic Hypertension in the Elderly Program randomized 4,736 adults aged 60 plus with systolic pressure over 160 to chlorthal...
HYVET
The Hypertension in the Very Elderly Trial randomized 3,845 patients aged 80 and over with systolic pressure over 160 to indapamid...
CONSENSUS
The Cooperative North Scandinavian Enalapril Survival Study randomized 253 patients with severe congestive heart failure, NYHA cla...
SOLVD-Treatment
The Studies of Left Ventricular Dysfunction treatment arm randomized 2,569 patients with chronic heart failure and ejection fracti...
MERIT-HF
The Metoprolol CR XL Randomized Intervention Trial in Congestive Heart Failure randomized 3,991 patients with moderate heart failu...
RALES
The Randomized Aldactone Evaluation Study randomized 1,663 patients with severe heart failure, ejection fraction under 35 percent,...
PARADIGM-HF
The Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality trial randomized 8,442 heart failure patients...
DAPA-HF
Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure randomized 4,744 patients with reduced ejection fraction to the ...
RE-LY
The Randomized Evaluation of Long Term Anticoagulation Therapy trial randomized 18,113 atrial fibrillation patients to blinded dos...
ROCKET AF
ROCKET AF randomized 14,264 atrial fibrillation patients to rivaroxaban 20 mg daily or warfarin. Rivaroxaban was non inferior for ...
ARISTOTLE
The Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial randomized 18,201 patients to ap...
PLATO
The Platelet Inhibition and Patient Outcomes trial randomized 18,624 acute coronary syndrome patients to ticagrelor or clopidogrel...
COURAGE
The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation trial randomized 2,287 patients with stable coron...
ISCHEMIA
The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches randomized 5,179 patients with mo...
ORBITA
ORBITA enrolled 230 patients with single vessel stable angina and, after a medication optimization phase, randomized 200 to PCI or...
SYNTAX
The Synergy between PCI with Taxus and Cardiac Surgery trial randomized 1,800 patients with three vessel or left main disease to p...
FREEDOM
The Future Revascularization Evaluation in Patients with Diabetes Mellitus trial randomized 1,900 diabetic patients with multivess...
VA Cooperative Hypertension Study
Led by Edward Freis at Veterans Administration hospitals, the study randomized men with severe diastolic hypertension to a combina...
Physicians' Health Study
The Physicians' Health Study randomized 22,071 US male physicians in a factorial design to aspirin 325 mg every other day, beta ca...
GISSI
The first Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico trial randomized more than 11,000 patients wi...
Women's Health Initiative
The Women's Health Initiative randomized 16,608 postmenopausal women with an intact uterus to conjugated estrogens plus medroxypro...