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SHEP
About the Trial
The Systolic Hypertension in the Elderly Program randomized 4,736 adults aged 60 plus with systolic pressure over 160 to chlorthalidone based treatment or placebo. Treatment reduced strokes by 36 percent, major cardiovascular events by 32 percent, and heart failure by 49 percent. Before SHEP, many doctors believed elevated systolic pressure was a normal part of aging that should not be treated, and that treating it was dangerous. SHEP demolished that dogma and established that isolated systolic hypertension, the most common form in older people, is worth treating. Chlorthalidone and the stepped care approach entered mainstream geriatric medicine.
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