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JUPITER
About the Trial
Justification for the Use of Statins in Prevention trial tested rosuvastatin in 17,802 healthy people with low LDL under 130 but elevated high sensitivity CRP, a marker of inflammation. The trial stopped early after a median of 1.9 years: statin reduced major cardiovascular events by 44 percent and all cause mortality by 20 percent. JUPITER expanded statin indications to inflammation identified risk and sparked intense debate about treating healthy people. Critics noted modest absolute benefit and diabetes signal. It remains a landmark in risk stratification, showing that inflammation measured by CRP adds predictive power beyond cholesterol.
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