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ClinicalTrialsDB
107 landmark clinical trials that changed medical practice. From drugs that saved millions to cautionary tales that reshaped drug testing, understand the evidence behind modern medicine.
Landmark Trials
RECOVERY
The Randomised Evaluation of COVID 19 Therapy platform trial in the UK randomized over 11,000 hospitalized COVID patients to multi...
DCCT
The Diabetes Control and Complications Trial randomized 1,441 type 1 diabetes patients to intensive versus conventional insulin th...
4S
The Scandinavian Simvastatin Survival Study randomized 4,444 patients with prior heart attack or angina and high cholesterol to si...
ISIS-2
The Second International Study of Infarct Survival randomized 17,187 heart attack patients to streptokinase, aspirin, both, or nei...
CAST
The Cardiac Arrhythmia Suppression Trial tested whether suppressing ventricular premature beats after heart attack prevented death...
NINDS rt-PA Stroke Trial
The NINDS trial randomized 624 acute ischemic stroke patients to intravenous tPA or placebo within 3 hours of onset. At 3 months, ...
Pfizer COVID-19 Vaccine Trial
The C4591001 trial randomized 43,548 participants to BNT162b2 mRNA vaccine or placebo. Over 170 COVID cases accrued: 8 in vaccine ...
HPTN 052
HIV Prevention Trials Network 052 randomized 1,763 HIV discordant couples to immediate versus delayed antiretroviral therapy for t...
PARADIGM-HF
The Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality trial randomized 8,442 heart failure patients...
IRIS
The International Randomized Study of Interferon and STI571 randomized 1,106 newly diagnosed chronic phase CML patients to imatini...