Not medical advice. This site is general information only. In an emergency call your local emergency number. For advice about your own health, speak to a doctor, pharmacist or other qualified health professional.
CONSENSUS
About the Trial
The Cooperative North Scandinavian Enalapril Survival Study randomized 253 patients with severe congestive heart failure, NYHA class IV, to enalapril or placebo. Enalapril reduced 6 month mortality from 44 percent to 26 percent and 1 year mortality by 31 percent. This small trial in the sickest patients proved the renin angiotensin system drives progression of heart failure, not just hypertension. Along with SOLVD, it established ACE inhibitors as the foundation of heart failure therapy. CONSENSUS demonstrated that a pathophysiologically targeted drug could transform a uniformly fatal disease, launching the modern neurohormonal era of heart failure treatment.
Related Trials
DCCT
The Diabetes Control and Complications Trial randomized 1,441 type 1 diabetes patients to intensive versus conventional insulin th...
UKPDS
The UK Prospective Diabetes Study followed over 5,000 newly diagnosed type 2 diabetes patients for a median of 10 years. Intensive...
ACCORD
The Action to Control Cardiovascular Risk in Diabetes trial tested intensive glucose control targeting HbA1c under 6.0 percent in ...
ADVANCE
ADVANCE randomized 11,140 type 2 diabetes patients to intensive gliclazide based glucose control or standard therapy. Intensive co...