Not medical advice. This site is general information only. In an emergency call your local emergency number. For advice about your own health, speak to a doctor, pharmacist or other qualified health professional.
VA Cooperative Hypertension Study
About the Trial
Led by Edward Freis at Veterans Administration hospitals, the study randomized men with severe diastolic hypertension to a combination of hydrochlorothiazide, reserpine, and hydralazine or to placebo. The excess of strokes, heart failure, kidney damage, and other serious complications in the placebo group was so striking that this arm was stopped early, with results published in JAMA in 1967. A 1970 report extended the benefit to men with moderate hypertension. Before the study, many physicians considered high blood pressure a compensatory response that should not be lowered. The trial launched the era of antihypertensive treatment, and Freis received the Lasker Award in 1971.
Related Trials
DCCT
The Diabetes Control and Complications Trial randomized 1,441 type 1 diabetes patients to intensive versus conventional insulin th...
UKPDS
The UK Prospective Diabetes Study followed over 5,000 newly diagnosed type 2 diabetes patients for a median of 10 years. Intensive...
ACCORD
The Action to Control Cardiovascular Risk in Diabetes trial tested intensive glucose control targeting HbA1c under 6.0 percent in ...
ADVANCE
ADVANCE randomized 11,140 type 2 diabetes patients to intensive gliclazide based glucose control or standard therapy. Intensive co...