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Prevention Trials
23 trials
Diabetes Prevention Program
The DPP randomized 3,234 people with impaired glucose tolerance to metformin, intensive lifestyle modification, or placebo. Lifest...
LOOK AHEAD
LOOK AHEAD randomized over 5,100 overweight or obese adults with type 2 diabetes to intensive lifestyle intervention targeting 7 p...
WOSCOPS
The West of Scotland Coronary Prevention Study randomized 6,595 healthy men with elevated LDL cholesterol to pravastatin or placeb...
Heart Protection Study
HPS randomized 20,536 UK adults with vascular disease or diabetes to simvastatin 40 mg or placebo regardless of baseline cholester...
JUPITER
Justification for the Use of Statins in Prevention trial tested rosuvastatin in 17,802 healthy people with low LDL under 130 but e...
HOPE
The Heart Outcomes Prevention Evaluation trial randomized 9,297 patients with vascular disease or diabetes plus one risk factor to...
SHEP
The Systolic Hypertension in the Elderly Program randomized 4,736 adults aged 60 plus with systolic pressure over 160 to chlorthal...
NSABP P-1
The Breast Cancer Prevention Trial randomized 13,388 women at elevated breast cancer risk to 5 years of tamoxifen or placebo. Tamo...
NASCET
The North American Symptomatic Carotid Endarterectomy Trial randomized 2,885 patients with recent TIA or minor stroke and carotid ...
HPTN 052
HIV Prevention Trials Network 052 randomized 1,763 HIV discordant couples to immediate versus delayed antiretroviral therapy for t...
iPrEx
The Pre Exposure Prophylaxis Initiative trial randomized 2,499 men and transgender women who have sex with men to daily oral tenof...
FUTURE II
The Females United to Unilaterally Reduce Endo Ectocervical Disease trial randomized over 12,000 young women to the quadrivalent H...
Pfizer COVID-19 Vaccine Trial
The C4591001 trial randomized 43,548 participants to BNT162b2 mRNA vaccine or placebo. Over 170 COVID cases accrued: 8 in vaccine ...
Liggins Steroid Trial
Graham Liggins and Ross Howie randomized women at risk of preterm delivery to betamethasone or placebo. Steroids given before birt...
Magpie
The Magpie Trial randomized 10,141 women with pre eclampsia to magnesium sulfate or placebo. Magnesium more than halved eclampsia,...
VITAL
The Vitamin D and Omega 3 Trial randomized 25,871 generally healthy adults to vitamin D 2000 IU, omega 3, both, or placebo in a fa...
Salk Polio Vaccine Field Trial
Organized by the National Foundation for Infantile Paralysis and directed by Thomas Francis Jr. at the University of Michigan, the...
Physicians' Health Study
The Physicians' Health Study randomized 22,071 US male physicians in a factorial design to aspirin 325 mg every other day, beta ca...
MRC Vitamin Study
The Medical Research Council Vitamin Study randomized women in several countries who had previously had a pregnancy affected by a ...
Women's Health Initiative
The Women's Health Initiative randomized 16,608 postmenopausal women with an intact uterus to conjugated estrogens plus medroxypro...
Aceh Vitamin A Trial
Alfred Sommer and colleagues randomized 450 villages in Aceh province, Indonesia, so that preschool children in half the villages ...
RV144
RV144 randomized 16,402 adult volunteers in Thailand to a prime boost regimen of the ALVAC-HIV canarypox vector vaccine followed b...
Moderna COVE Trial
The Coronavirus Efficacy trial randomized 30,420 adults at sites across the United States to two doses of Moderna's mRNA-1273 vacc...