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Liggins Steroid Trial
About the Trial
Graham Liggins and Ross Howie randomized women at risk of preterm delivery to betamethasone or placebo. Steroids given before birth cut neonatal respiratory distress syndrome by roughly half and reduced neonatal death, with greatest effect when delivery occurred roughly 1 to 7 days after treatment. The 1972 paper, from Auckland, quietly founded one of the most cost effective interventions in perinatal medicine. It took a 1994 NIH consensus and a landmark meta analysis by Crowley to drive universal adoption. Antenatal corticosteroids remain widely used before anticipated preterm birth, and the work made Liggins a central figure in perinatal medicine.
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