Not medical advice. This site is general information only. In an emergency call your local emergency number. For advice about your own health, speak to a doctor, pharmacist or other qualified health professional.
ACTG 320
About the Trial
AIDS Clinical Trials Group 320 randomized 1,156 HIV patients with CD4 under 200 to zidovudine plus lamivudine with or without indinavir. The triple arm reduced AIDS defining illness or death by about 50 percent, mostly opportunistic infections, and cut HIV RNA below detection. With other protease inhibitor trials of 1996 and 1997, it underpinned the so called Lazarus effect as gravely ill patients recovered. US AIDS deaths fell by more than half within a few years. ACTG 320 fixed the standard of three drug combination antiretroviral therapy that, modernized over decades, can suppress the virus long term and makes HIV a chronic manageable disease.
Related Trials
DCCT
The Diabetes Control and Complications Trial randomized 1,441 type 1 diabetes patients to intensive versus conventional insulin th...
UKPDS
The UK Prospective Diabetes Study followed over 5,000 newly diagnosed type 2 diabetes patients for a median of 10 years. Intensive...
ACCORD
The Action to Control Cardiovascular Risk in Diabetes trial tested intensive glucose control targeting HbA1c under 6.0 percent in ...
ADVANCE
ADVANCE randomized 11,140 type 2 diabetes patients to intensive gliclazide based glucose control or standard therapy. Intensive co...